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Taurocholic acid

CAS No. 81-24-3

Taurocholic acid( —— )

Catalog No. M31531 CAS No. 81-24-3

Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Taurocholic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
  • Description
    Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
  • In Vitro
    Taurocholic acid (100 μM, 24 h) decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients.Taurocholic acid (100 μM, 24 h) decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells.
  • In Vivo
    Animal Model:C57BL/6 mice Dosage:100-mg/kg Administration:oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks Result:Reduced the percentage of NK and CD3+CD8+ T cells.Increases serum HBsAg, HBeAg, and HBV DNA levels.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    81-24-3
  • Formula Weight
    515.7
  • Molecular Formula
    C26H45NO7S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (193.91 mM)
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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